A Prospective Observational Study Comparing Coronary Blood Flow and Microcirculation Assessment Between Photon-Counting CT and N-13 Ammonia PET

A Prospective Observational Study Comparing Coronary Blood Flow and Microcirculation Assessment Between Photon-Counting CT and N-13 Ammonia PET - Comparison of coronary blood flow and microcirculation assessment between photon-counting CT and N-13 ammonia PET

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000059360

Enrollment

Registered

2025-10-14

Start date

2025-10-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Symptomatic Stable Angina Pectoris

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients clinically diagnosed with symptomatic stable angina pectoris Aged 20 years or older and under 85 years at the time of obtaining informed consent Physically suitable for both cardiac CT and PET examinations, and able to undergo pharmacologic stress testing (e.g., adenosine) Provided written informed consent after receiving adequate explanation of the study

Exclusion criteria

Exclusion criteria: Patients with obesity that may cause technical difficulty or significant image degradation (e.g., BMI > 35) Patients with significant arrhythmias (e.g., frequent premature beats or atrial fibrillation) that preclude stable ECG gating, as judged by the investigator Pregnant or breastfeeding women Patients with severe renal dysfunction (eGFR < 30 mL/min/1.73m2) Patients with severe hepatic dysfunction (equivalent to Child-Pugh class C) Patients with a history of severe allergy to iodinated contrast agents or pharmacologic stress agents (e.g., adenosine) Patients with clinically significant comorbidities (e.g., acute heart failure) that make participation unsafe Patients deemed inappropriate for participation by the principal investigator or sub-investigator

Design outcomes

Primary

Measure	Time frame
The Pearson correlation coefficient and Bland-Altman agreement between coronary flow reserve (CFR) values derived from photon-counting CT and those obtained by N-13 ammonia PET.	—

Countries

Japan

Contacts

Public ContactMasahiro Hoshino

Institute of Science Tokyo Hospital Department of cardiology

hoshino.masahiro@tmd.ac.jp03-3813-6111

Outcome results