Efficacy of Expectant Management for Preterm Subclinical Intra-Amniotic Infection

Efficacy of Expectant Management for Preterm Subclinical Intra-Amniotic Infection - Expectant Management for Intra-Amniotic Infection

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000059353

Enrollment

Registered

2026-03-31

Start date

2025-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm Subclinical Intra-Amniotic Infection

Interventions

None listed

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: (1) singleton gestation between 20+0 and 33+6 weeks; (2) transabdominal amniocentesis performed to assess microbiological and inflammatory status of the amniotic cavity; (3) diagnosis of intra-amniotic infection; and (4) expectant management.

Exclusion criteria

Exclusion criteria: (1) decision to terminate pregnancy after a diagnosis of intra-amniotic infection; (2) antimicrobial administration within seven days prior to amniocentesis; (3) secondary intra-amniotic infection; (4) fetal congenital structural or chromosomal abnormalities; and (5) induction of labor within 48 h of infection diagnosis due to oligohydramnios or infection itself.

Design outcomes

Primary

Measure	Time frame
the proportion of patients in which the interval from the diagnosis of infection to delivery exceeded 48 h without exacerbation of IAI, as compared between the U/Mh-only and other bacteria groups.	—

Secondary

Measure	Time frame
Secondary outcome was assessed at the same interval, but extended to 168 h.	—

Countries

Japan

Contacts

Public ContactMakoto Nomiyama

NHO Saga Hospital Department of Obstetrics and Gynecology

nomiyama8522@gmail.com0952307141

Outcome results