refractory epilepsy, parkinson'
Conditions
Interventions
None listed
Sponsors
Keio University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients diagnosed with drug-resistant epilepsy or movement disorders, including Parkinson's disease, essential tremor, or dystonia, who are indicated for intracranial electrode implantation at the Department of Neurosurgery, Keio University School of Medicine. Patients who provide written informed consent to participate in this study. For minors or adults with insufficient decision-making capacity, written consent will be obtained from their legally authorized representative.
Exclusion criteria
Exclusion criteria: Patients who develop severe postoperative complications following electrode implantation. Patients deemed by the principal investigator or co-investigators to be unsuitable for participation in this study for any other reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Outcome Measures (and Their Indicators / Evaluation Methods): To examine the relationship between electrophysiological activity at individual electrodes or functional connectivity across multiple brain regions and postoperative outcomes, including seizure control and improvement in motor symptoms. EEG/LFP data obtained from the implanted electrodes will be analyzed offline to assess correlations with clinical data. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary Outcome Measures (and Their Indicators, Evaluation Methods): Accuracy of electrode implantation, to be evaluated using patient's medical records and imaging data. | — |
Countries
Japan
Contacts
Public ContactKenzo Kosugi
Keio University Hospital Department of Neurosurgery
Outcome results
None listed