Study on Chest CT Findings Predictive of Visceral Pleural Invasion (VPI) in Lung Cancer

Radiological Features of Visceral Pleural Invasion (VPI) in Primary Lung Cancer on Preoperative Chest CT: A Retrospective Observational Study - PRE-VPI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000059277

Enrollment

300

Registered

2025-10-06

Start date

2025-01-31

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who underwent surgical resection for primary lung cancer at [Okayama university hospital] from January 1, 2012 to December 31, 2019, with a final pathological diagnosis of non-small cell lung cancer (NSCLC). Lesions meeting all of the following: 1.Contact with the visceral pleura on preoperative thin-section CT (slice thickness <= 2.5 mm) 2.Part-solid or pure ground-glass nodules with solid component diameter <=30 mm 3.Age =>18 years at presentation

Exclusion criteria

Exclusion criteria: 1.Any neoadjuvant therapy prior to surgery 2.Final pathology other than NSCLC 3.Lack of thin-section CT or indeterminate pleural contact 4.Solid component diameter <30 mm 5.Missing data precluding assessment of the primary outcome (pathological VPI)

Design outcomes

Primary

Measure	Time frame
Presence or absence of pathological visceral pleural invasion (VPI), determined from postoperative histopathological examination of resected specimens. (Time frame: At the time of surgery)	—

Secondary

Measure	Time frame
To evaluate relapse-free survival (RFS) and overall survival (OS) according to the presence or absence of visceral pleural invasion (VPI).	—

Countries

Japan

Contacts

Public Contactnaohiro hayashi

Okayama University Hospital Department of General Thoracic Surgery and Brest and Endocrinological Surgery

pqak0q2o@s.okayama-u.ac.jp+81-86-235-7265

Outcome results