High-protein nutrition in ICU patients undergoing advanced early mobilization

High-protein nutrition in ICU patients undergoing advanced early mobilization - High-protein nutrition in ICU patients undergoing advanced early mobilization

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000059233

Enrollment

Registered

2025-09-29

Start date

2025-09-30

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ICU patients

Interventions

In the control group, nutritional administration is targeted at the lower limit of the protein level (1.2 g/kg/day) indicated in each guideline. The intervention group will be fed at 1.8 g/kg/day of p

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria were (1) general or emergency (ICU) inpatients aged 18 years or older, (2) independent of ADLs prior to admission, and (3) patients expected to remain on a ventilator for at least 48 hours.

Exclusion criteria

Exclusion criteria: Exclusion criteria are (1) scheduled surgical patients, (2) patients weighing 200 kg or more (due to device weight capacity of up to 200 kg), (3) patients admitted for neuromuscular disease, (4) patients with leg loss or load limitation due to post-hospitalization surgery, (5) patients transferred after 48 hours of ventilation, (6) patients for whom enteral nutrition is impossible; and (7) patients expected to die within 7 days.

Design outcomes

Primary

Measure	Time frame
The primary outcome is the motor score of the Functional Independence Measure (FIM) at hospital discharge	—

Secondary

Measure	Time frame
At ICU discharge: Functional Status Score for the ICU (FSS-ICU) [27], Medical Research Council (MRC) score, and ICU length of stay. At 14 days after ICU discharge: FIM motor, FIM cognitive (FIM cog), Mini-Mental State Examination (MMSE), body composition parameters, MRC score, and Brief Pain Inventory (BPI). At hospital discharge: MRC score, FIM cog, body composition parameters, BPI, length of hospital stay, and mortality. At 60 days after hospital discharge: FIM motor score, MRC score, FIM cog, MMSE score, body composition parameters, and BPI	—

Measure

Time frame

At ICU discharge: Functional Status Score for the ICU (FSS-ICU) [27], Medical Research Council (MRC) score, and ICU length of stay. At 14 days after ICU discharge: FIM motor, FIM cognitive (FIM cog), Mini-Mental State Examination (MMSE), body composition parameters, MRC score, and Brief Pain Inventory (BPI). At hospital discharge: MRC score, FIM cog, body composition parameters, BPI, length of hospital stay, and mortality. At 60 days after hospital discharge: FIM motor score, MRC score, FIM cog, MMSE score, body composition parameters, and BPI

—

Countries

Japan

Contacts

Public ContactGinga Suzuki

Toho University Omori Medical Center Critical Care Center

ginga.suzuki@med.toho-u.ac.jp0337624151

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026