A study on the association between intestinal barrier function and disease onset

A prospective cohort study on the association between intestinal barrier function and disease onset - A prospective cohort study on the association between intestinal barrier function and disease onset

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000059184

Enrollment

2000

Registered

2025-09-25

Start date

2025-09-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adults

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Participants in the Tohoku Medical Megabank Project cohort study who took part in both the baseline survey and the second survey, with the baseline survey being the community-based cohort.

Exclusion criteria

Exclusion criteria: 1. Participants who requested to opt out of providing samples or information for this study during the information disclosure period. 2. Participants with a history of irritable bowel syndrome, ulcerative colitis, Crohn's disease, or colorectal cancer at the time of the baseline survey. 3. Participants who had taken within the previous two weeks antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), gastroprotective agents, metformin, immunosuppressants, or other medications reported to affect intestinal barrier function. 4. Participants deemed unsuitable as participants by the principal investigator.

Design outcomes

Primary

Measure	Time frame
To investigate the association between intestinal barrier markers and disease onset in cohort data.	—

Secondary

Measure	Time frame
To investigate the association between intestinal barrier markers and disease onset, incorporating metabolomic analysis data.	—

Countries

Japan

Contacts

Public ContactYuka Katsukura

Meiji Holdings Co., Ltd. Wellness Science Labs

yuka.katsukura@meiji.com042-632-5842

Outcome results