A Study on the Interaction Between Anesthetic and Analgesic Drugs

A interaction of sedative effect between Propofol and Remifentanil - A interaction of sedative effect between Propofol and Remifentanil

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000059116

Enrollment

Registered

2025-10-01

Start date

2025-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who undergo surgery under general anesthesia

Interventions

Remifentanil 0 ng/mL group Remifentanil 3.0 ng/mL group Remifentanil 4.0 ng/mL group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The study will include patients undergoing surgery under general anesthesia at Kansai Medical University Hospital. To select surgeries with stable hemodynamics, patients scheduled for breast surgery or laparoscopic cholecystectomy will be included.

Exclusion criteria

Exclusion criteria: Exclusion criteria included serious liver dysfunction, renal dysfunction, or psychological disorders, pregnancy, lactation or receipt of psychotropic drugs, and allergy to propofol or remifentanil.

Design outcomes

Primary

Measure	Time frame
The relationship between propofol concentrations at loss of responsiveness, maximum power in the alpha frequency band, and appearance of burst suppression patterns on EEG at predicted remifentanil effect-site concentrations of 0 ng/ml, 3.0 ng/ml, and 4.0 ng/ml.	—

Countries

Japan

Contacts

Public ContactSatoshi Aihara

Kansai Medical University Department of Anesthesiology

aihara.sat@kmu.ac.jp0728040101

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026