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Preventive Strategies for Perioperative Neurocognitive Disorders with a Focus on Sleep Disturbances: A Prospective Observational Study

Preventive Strategies for Perioperative Neurocognitive Disorders with a Focus on Sleep Disturbances: A Prospective Observational Study - The SPND Project (Sleep and Perioperative Neurocognitive Disorders Project)

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000058993
Enrollment
300
Registered
2025-09-05
Start date
2026-04-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative Neurocognitive Disorders (PND)

Interventions

None listed

Sponsors

Hamamatsu University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients who meet all of the following criteria will be included: 1. Patients undergoing surgery under general anesthesia at Hamamatsu University Hospital who are admitted to the ICU. 2. Patients judged by the attending physician to be eligible for participation in this study. 3. Patients who have provided written informed consent for participation in this study.

Exclusion criteria

Exclusion criteria: Patients who meet any of the following criteria will be excluded from the study: 1. Patients from whom collection of residual blood samples is difficult, requiring additional blood sampling, and who either did not provide consent or withdrew consent. 2. Patients judged by the attending physician to be inappropriate for participation. 3. Patients who already present with cognitive impairment at the time of hospital admission or in the preoperative phase.

Design outcomes

Primary

MeasureTime frame
PND onset and the dynamics of biological and digital biomarkers, together with RNA signaling pathways, associated with sleep and psychiatric disorders

Countries

Japan

Contacts

Public ContactTatsuya Yagi

Hamamatsu University School of Medicine Department of Hospital Pharmacy

yagi5922@hama-med.ac.jp0534352767

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026