Database study on the association between serum calcium control status and incidence of renal dysfunction in patients with chronic hypoparathyroidism

The association between serum calcium control status and incidence of renal dysfunction in patients with chronic hypoparathyroidism: a retrospective cohort study using medical institution-based data - The association between serum calcium control status and incidence of renal dysfunction in patients with chronic hypoparathyroidism: a retrospective cohort study using medical institution-based data

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000058988

Enrollment

1000

Registered

2025-09-05

Start date

2025-09-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypoparathyroidism

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who meet all the following criteria will be included. (1) Patients who satisfied any of the hypoparathyroidism criteria for the first time between April 1, 2010 and November 30, 2023 (2) Patients having medical records for no less than 180 days prior to (1) (3) Patients who received an outpatient prescription for conventional therapy from (1) to between 180 days and 300 days after (1) (4) Patients with at least one prescription of conventional therapy from (1) to the day before (3) (5) Patients who had received medical care since (3) (6) Patients who had serum calcium levels and serum albumin levels, obtained on the same day, from (3) to 90 days before (3) (7) Patients who had eGFR values obtained from (3) to 90 days before (3) (8) Patients who had at least one recorded eGFR value of 30mL/min/1.73m^2 or more from 90 days before to 90 days after (1)

Exclusion criteria

Exclusion criteria: Patients who meet any of the following criteria will be excluded. (1) Patients who satisfied any one of the hypoparathyroidism criteria from 1 day to 180 days before inclusion criterion (1) (2) Patients with diagnosis codes for pseudo-hypoparathyroidism from 1 day to 180 days before (3) (3) Patients with at least one recorded eGFR value less than 15mL/min/1.73m^2 between inclusion criteria (1) to (3) (4) Patients with a history of end-stage kidney disorders between inclusion criteria (1) to (3)

Design outcomes

Primary

Measure	Time frame
Incidence of renal dysfunction, based on status of serum calcium control	—

Secondary

Measure	Time frame
- Incidence of urinary stones (including nephrolithiasis and nephrocalcinosis), based on status of serum calcium control - Changes in laboratory test values, based on status of serum calcium control	—

Countries

Japan

Contacts

Public ContactMana Kujirai

Teijin Pharma Limited Medical Science Department

tpm-com@umin.ac.jp03-3506-4140

Outcome results