Exploration of biomarkers for predicting and preventing postoperative nausea and vomiting

Exploration of biomarkers for predicting and preventing postoperative nausea and vomiting - Exploration of biomarkers for predicting postoperative nausea and vomiting

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000058961

Enrollment

Registered

2025-09-08

Start date

2025-09-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inpatients undergoing oral surgery under general anesthesia

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inpatients undergoing oral surgery under general anesthesia (men and women classified as ASA physical status 1 or 2)

Exclusion criteria

Exclusion criteria: Cases with a scheduled surgery time of less than one hour, patients with allergies to the medications used, patients who expressed refusal to participate in this study (including verbally), and other patients deemed unsuitable by the principal investigator.

Design outcomes

Primary

Measure	Time frame
Salivary amylase, cortisol, and serotonin prior to general anesthesia	—

Secondary

Measure	Time frame
Postoperative (upon return to room, 3 hours after return to room, the following morning) PONV level VAS assessment, age, gender, height, weight, medical history, presence of preoperative complications, smoking and drinking status, preoperative blood test results, anesthesia duration, surgery duration, administered medications, vital data (ECG, heart rate, blood pressure (non-invasive and invasive arterial pressure), pulse rate, respiratory rate, SpO2, neuromuscular blockade monitor data, fluid administration volume, blood loss volume, and the volume and consistency of gastric contents immediately prior to awakening as measured by the nasogastric tube placed intraoperatively).	—

Measure

Time frame

Postoperative (upon return to room, 3 hours after return to room, the following morning) PONV level VAS assessment, age, gender, height, weight, medical history, presence of preoperative complications, smoking and drinking status, preoperative blood test results, anesthesia duration, surgery duration, administered medications, vital data (ECG, heart rate, blood pressure (non-invasive and invasive arterial pressure), pulse rate, respiratory rate, SpO2, neuromuscular blockade monitor data, fluid administration volume, blood loss volume, and the volume and consistency of gastric contents immediately prior to awakening as measured by the nasogastric tube placed intraoperatively).

—

Countries

Japan

Contacts

Public ContactUno Imaizumi

Kanagawa Dental University Department of Anesthesiology

imaizumi@kdu.ac.jp046-822-8896

Outcome results