Skip to content

Prospective and Retrospective Research for the Diagnosis of Osteoporosis: Validation and Establishment of Vertebral Hounsfield Unit

Prospective and Retrospective Research for the Diagnosis of Osteoporosis: Validation and Establishment of Vertebral Hounsfield Unit - HU-PROVE study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000058939
Enrollment
2800
Registered
2025-08-30
Start date
2025-08-31
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ostoporosis

Interventions

None listed

Sponsors

Osaka Metropolitan University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Selection Criteria 1 Patients aged 20-44 years at the time of lumbar CT imaging. Patients with CT scans that include the lumbar spine between L1-4. Selection Criteria 2 Patients aged 50 years or older at the time of lumbar CT imaging for lumbar disease diagnosis. Patients who underwent CT examinations including the lumbar spine between L1-L4. Patients with DXA data obtained within 6 months of the lumbar CT imaging date at the time of lumbar disease diagnosis. Patients with spinal X-rays available at the 2-year point within 6 months and 4-year point within 1 year from the lumbar CT imaging date at the time of lumbar disease diagnosis.

Exclusion criteria

Exclusion criteria: Patients suspected of having scoliosis 10 or more degrees or secondary osteoporosis such as long-term steroid use, hyperparathyroidism, hyperthyroidism, hypogonadism, Cushing syndrome, diabetes, chronic kidney disease, chronic obstructive pulmonary disease, etc. Patients who have undergone spinal fusion surgery. Patients suspected of having infection or tumor.

Design outcomes

Primary

MeasureTime frame
Calculate the reference values of bone mineral density. Compare the incidence of vertebral fractures according to the presence or absence of osteoporosis.

Secondary

MeasureTime frame
Non-vertebral fractures (proximal humerus, proximal femur, pelvis)

Countries

Japan

Contacts

Public ContactHiroshi Taniwaki

Osaka Metropolitan University Orthopaedic Surgery

tanishi517@gmail.com06-6645-3851

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026