Adults who are independent in activities of daily living
Conditions
Interventions
An 8-week lifestyle modification intervention program, consisting of dietary guidance, fasting, exercise, supplementation, yoga, cognitive training, and thermal therapy, will be provided to individual
Sponsors
Juntendo University
Selg corporation.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Men and women who are independent in activities of daily living will be eligible.
Exclusion criteria
Exclusion criteria: systemic infection; acute or chronic viral hepatitis; poorly controlled diabetes mellitus; severe renal or hepatic dysfunction; serious cardiovascular or cerebrovascular disease within the past 6 months; presence of a pacemaker; severe gastrointestinal disease or gastrointestinal surgery within the past 12 months; active malignancy within the past 5 years; current pregnancy or planned pregnancy; and breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Physical Function: Cardiopulmonary exercise testing (peak VO2) Knee extension strength Muscle mass by urinary D3-creatine dilution method (CT, MRI, DXA) Cognitive Function: Cambridge Neuropsychological Test Automated Battery (CANTAB, Cambridge Cognition): executive function, attention, processing speed, and memory Immune Function: Ex vivo naive immune responses IMM-AGE score CD4+:CD8+ ratio Lymphocyte-to-neutrophil ratio Multiplex assays including the SASP Index Aging-related Biomarkers: Epigenetic clocks Telomere length Mosaic loss of chromosome Y (mLOY) | — |
Secondary
| Measure | Time frame |
|---|---|
| Proteomic analysis RNA sequencing (RNA-seq) Personal Health Record (PHR) Continuous glucose monitoring Clinical data Body composition Electroencephalography (EEG) Gut microbiota analysis Handgrip strength Locomotive function test or Five-times Sit-to-Stand test Gait speed measurement | — |
Countries
Japan
Contacts
Public ContactYoshihiro Ikehata
Juntendo University Hospital department of Urology
Outcome results
None listed