Association Between Cumulative Triple Low Duration (Intraoperative Hypotension, Low BIS Values, and Low Inhaled Anesthetic Concentrations) and Postoperative Outcomes and Preoperative Frailty in Patients Undergoing Transcatheter Aortic Valve Replacement: A Retrospective Observational Study

Association Between Cumulative Triple Low Duration (Intraoperative Hypotension, Low BIS Values, and Low Inhaled Anesthetic Concentrations) and Postoperative Outcomes and Preoperative Frailty in Patients Undergoing Transcatheter Aortic Valve Replacement: A Retrospective Observational Study - Association between cumulative time of triple low (intraoperative hypotension, low BIS value, low inhaled anesthetic concentration) and postoperative outcomes, and preoperative frailty

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000058870

Enrollment

376

Registered

2025-08-25

Start date

2025-08-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe aortic valve stenosis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who underwent planned transcatheter aortic valve implantation for severe aortic stenosis at our hospital between December 2023 and April 2025

Exclusion criteria

Exclusion criteria: 1. Patients with missing BIS measurements during anesthesia for 15 minutes or more 2. Patients undergoing concurrent surgery 3. Patients with coexisting neuromuscular diseases

Design outcomes

Primary

Measure	Time frame
CK-MB value the day after surgery	—

Secondary

Measure	Time frame
Duke Activity Status Index, Preoperative frailty index, Preoperative NT-proBNP value, Postoperative CK/CK-MB, Postoperative troponin value, Number of days in CCU, Number of days in hospital, 30-day mortality after surgery, Postoperative complications (Clavien-Dindo)	—

Countries

Japan

Contacts

Public ContactHideki Hino

Osaka Metropolitan University Department of Anesthesiology

m1165192@yahoo.co.jp0666452186

Outcome results