Study on lipid and protein dynamics and ossification mechanisms in OPLL

Lipid and protein dynamics and ossification mechanisms in ossification of the posterior longitudinal ligament (OPLL) - OPLLLP (Lipid/Protein) Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000058853

Enrollment

110

Registered

2025-09-01

Start date

2025-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ossification of posterior longitudinal ligament

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged 20to90 years with thoracic or cervical OPLL scheduled for surgery Control group: nonOPLL patients aged 15to40 years scheduled for spinal surgery Written informed consent obtained from the patient or legally authorized representative

Exclusion criteria

Exclusion criteria: 1. Patients judged inappropriate by the attending physician 2. Patients who did not provide consent for this study

Design outcomes

Primary

Measure	Time frame
To clarify the relationship between lipid and protein dynamics within ligament tissue and the mechanisms of ossification in ossification of the posterior longitudinal ligament (OPLL).	—

Secondary

Measure	Time frame
To integrate radiologic findings (CT/MRI), serum lipid/adipokine markers, and exploratory genomic analyses to comprehensively evaluate the pathophysiological mechanisms underlying OPLL progression.	—

Countries

Japan

Contacts

Public ContactHirotaka Ogi

Hamamatsu University School of Medicine Department of Orthopedic Surgery

41246237@hama-med.ac.jp053-435-2111

Outcome results