spinal cerebellar degeneration
Conditions
Interventions
Rehabilitation interventions for patients with spinocerebellar degeneration are conducted within the scope of normal clinical practice and do not require the use of special medical equipment. Interven
s disease-related disorders, autoimmune disorders) who are receiving treatment at our hospital'
s neurology department. Rehabilitation interventions within the normal clinical range will be implemented as needed, in the same manner as in the intervention group.
Sponsors
National Center of Neurology and Psychiatry
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The study includes patients diagnosed with SCD at a medical institution (including those with an undetermined causative gene). Additionally, patients diagnosed with spinocerebellar degeneration or MSA-C by our neurology department are included. Criteria such as disease stage or duration of illness are not set to capture the distribution of evaluation results. Control group 1. Healthy adults matched with the study participants in terms of age and gender Patients with neurological disorders other than SCD who are under the care of our Department of Neurology (e.g., Parkinson's disease-related disorders, autoimmune diseases) To clearly distinguish from cerebellar disorders 2. Individuals who have received an explanation of the study and have provided informed consent to participate as volunteers.
Exclusion criteria
Exclusion criteria: 1) Severe heart disease: unstable angina, myocardial infarction within a short period after onset, decompensated congestive heart failure, uncontrolled arrhythmia, severe aortic stenosis, active myocarditis, endocarditis, etc. 2) Uncontrolled hypertension 3) Acute systemic disease or fever 4) Recent pulmonary embolism, acute pulmonary edema, or severe pulmonary hypertension 5) Severe liver or kidney dysfunction 6) Severe cognitive impairment or severe mental illness 7) Other conditions deemed inappropriate by the principal investigator 8) Patients with a cardiac pacemaker, pacemaker electrodes, metallic heart valves, or metallic clips from brain aneurysm surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Ataxia assessment using infrared and laser depth cameras 2. Rhythm disorder assessment 3. Gait and standing analysis 4. Gait measurement using accelerometers and gyroscopes in smartphones and Bluetooth-connected earphones 5. Markerless motion capture using deep learning with clinical videos from RGB cameras 6. Standing adaptation learning tasks using an external stimulus device | — |
Secondary
| Measure | Time frame |
|---|---|
| Established evaluation items The following evaluations are basically the evaluation items necessary for clinical practice. Since SCD has a wide range of symptoms, not all evaluations are performed on all cases. Clinically, the necessary evaluation items are selected from among these for each patient. Physical therapists, occupational therapists, and speech-language pathologists collaborate to perform the following evaluations. 1. Edinburgh Handedness Test 2. Scale for the Assessment and Rating of Ataxia (SARA) 3. Balance Evaluation Systems Test 4. Simple Test for Evaluating Hand Function (STEF) 5. 9-Hole Peg Test 6. Mini Mental State Examination (MMSE) 7. Frontal Assessment Battery (FAB) 8. Gait Efficacy Scale 9. Activities-specific Balance Confidence (ABC) Scale 10. Grip Strength and Pinch Strength 11. Purdue Pegboard Test 12. Box and Block Test 13. Trail Making Test-J 14. Kana Collection Test 15. FIM 16. EQ-5D 17. Medical Expenses 18. Speech sound production test 19. Standard Daytime Speech Test (AMSD) 20. Voice Handicap Index: Japanese version (VHI-) 21. Monologue (Momotaro) 22. Acoustic analysis (instrumental analysis) 23. Auditory impression test 24. Swallowing function assessment 25. Schmahmann syndrome scale 26. Respiratory function test 27. MRI image 28. Unified Multiple Systems Atrophy Rating Scale (UMSARS) 29. Scale for Ocular motor Deficits in Ataxia (SODA) 30. Ataxia Functional Composite Scale (AFCS) 31. Composite Cerebellar Functional Severity Score (CCFS) 32. SCA Functional Index (SCAFI) 33. Friedreich ataxia rating scale-activity of daily living (FARS-ADL) 34. Patient-Reported Outcome Measure of Ataxia (PROM-Ataxia) 35. Score of Integrated Balance for Ataxia 36. Patient-reported satisfaction questionnaire 37. Profile of Mood States 2nd Edition | — |
Countries
Japan
Contacts
Public ContactYuji Takahashi
National Center of Neurology and Psychiatry Department of Neurology
Outcome results
None listed