Association between Acute Respiratory Acidosis and Hyperkalemia During Esophageal Cancer Surgery in the Prone Position: A Retrospective Observational Study

Association between Acute Respiratory Acidosis and Hyperkalemia During Esophageal Cancer Surgery in the Prone Position: A Retrospective Observational Study - PRO-K study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000058829

Enrollment

150

Registered

2025-08-19

Start date

2025-07-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who underwent thoracoscopic esophagectomy (including robot-assisted surgery) in the prone position.

Exclusion criteria

Exclusion criteria: Patients undergoing chronic dialysis Patients with severe electrolyte abnormalities (defined as a preoperative serum potassium level of 5.0 mEq/L or higher) Patients who received intraoperative massive transfusion (defined as having received a transfusion for a blood loss of 2000 ml or more)

Design outcomes

Primary

Measure	Time frame
The mean difference in serum potassium levels between the baseline (supine) and the intraoperative (prone) timepoints.	—

Secondary

Measure	Time frame
Factors Associated with Change in Serum Potassium (change in K+) Correlation between the change in K+ and changes in physiological variables (e.g., PaCO2, lactate). Multivariable analysis to identify independent factors associated with the magnitude of the change in K+. Sensitivity Analysis of the Primary Outcome Re-evaluation of the primary outcome after excluding cases with severe metabolic acidosis. Exploratory and Clinical Analyses Exploratory analysis of risk factors for clinically significant hyperkalemia (serum K+ > 5.0 mEq/L). Subgroup analyses based on preoperative renal function and bronchial blocker usage. Descriptive analysis of other acid-base parameters (e.g., HCO3-, BE).	—

Measure

Time frame

Factors Associated with Change in Serum Potassium (change in K+) Correlation between the change in K+ and changes in physiological variables (e.g., PaCO2, lactate). Multivariable analysis to identify independent factors associated with the magnitude of the change in K+. Sensitivity Analysis of the Primary Outcome Re-evaluation of the primary outcome after excluding cases with severe metabolic acidosis. Exploratory and Clinical Analyses Exploratory analysis of risk factors for clinically significant hyperkalemia (serum K+ > 5.0 mEq/L). Subgroup analyses based on preoperative renal function and bronchial blocker usage. Descriptive analysis of other acid-base parameters (e.g., HCO3-, BE).

—

Countries

Japan

Contacts

Public ContactSakura Okamoto

Aichi Medical University Hospital Department of Anesthesiology

sokamotoanes@gmail.com0561-62-3311

Outcome results