Study of the relationship between FLT accumulation and thymine synthesis pathway in lung cancer using PET imaging

Study of the relationship between FLT accumulation and thymine synthesis pathway in lung cancer using PET imaging - Study of the relationship between FLT accumulation and thymine synthesis pathway in lung cancer using PET imaging

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000058773

Enrollment

Registered

2025-08-12

Start date

2025-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-small cell lung cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with untreated non-small cell lung cancer confirmed by histological or cytological diagnosis, or with primary lung cancer strongly suspected by CT or FDG-PET imaging and scheduled for surgical resection. Patients who have been fully informed about their participation in this study, and who have given written consent of their own free will based on a thorough understanding of the study.

Exclusion criteria

Exclusion criteria: 1) Pregnant woman 2) Patients with metalic device in their body 3) Patients with claustrophobia 4) Patients with a long diameter of less than 2 cm of the solid component of the primary lung cancer on CT 5) Other cases attending physician it is determined unsuitable for registration of the study

Design outcomes

Primary

Measure	Time frame
Association of tumor FLT and FDG accumulation with TS expression in tumors.	—

Secondary

Measure	Time frame
The relationship between tumor FLT accumulation, FDG accumulation, the ratio of FLT accumulation to FDG accumulation, and tumor immunostaining (Ki67, TK1, TS, GLUT1) findings and thymidine concentration in tumors. The relationship between tumor FLT accumulation, FDG accumulation, ratio of FLT accumulation to FDG accumulation, and tumor immunostaining (Ki67, TK1, TS, GLUT1) findings and thymidine concentration in tumors and the response rate, progression-free survival, and overall survival to drug therapy including pemetrexed or S-1. The relationship between tumor FLT accumulation, FDG accumulation, ratio of FLT accumulation to FDG accumulation, and tumor immunostaining (Ki67, TK1, TS, GLUT1) findings and thymidine concentration in the tumor and tumor histology, presence of oncogenes, and level of PD-L1 expression.	—

Measure

Time frame

The relationship between tumor FLT accumulation, FDG accumulation, the ratio of FLT accumulation to FDG accumulation, and tumor immunostaining (Ki67, TK1, TS, GLUT1) findings and thymidine concentration in tumors. The relationship between tumor FLT accumulation, FDG accumulation, ratio of FLT accumulation to FDG accumulation, and tumor immunostaining (Ki67, TK1, TS, GLUT1) findings and thymidine concentration in tumors and the response rate, progression-free survival, and overall survival to drug therapy including pemetrexed or S-1. The relationship between tumor FLT accumulation, FDG accumulation, ratio of FLT accumulation to FDG accumulation, and tumor immunostaining (Ki67, TK1, TS, GLUT1) findings and thymidine concentration in the tumor and tumor histology, presence of oncogenes, and level of PD-L1 expression.

—

Countries

Japan

Contacts

Public ContactYukihiro Umeda

Faculty of Medical Sciences, University of Fukui Department of Respiratory Medicine

umeda@u-fukui.ac.jp0776-61-3111

Outcome results