A study to examine the safety and tolerability of a home-based exercise program after local therapy for liver cancer

A study to examine the safety and tolerability of a home-based exercise program after local therapy for liver cancer - Home-based Exercise for Adjuvant recovery after Liver cancer therapy

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000058730

Enrollment

Registered

2025-08-08

Start date

2025-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with liver cancer who underwent local therapy, aged 18 years or older, with a performance status (PS) of 0 or 1

Interventions

A 12-week home-based exercise program will be provided to patients aged 18 years or older who have been discharged after local therapy for liver cancer. The program includes resistance training using

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who have undergone local therapy for hepatocellular carcinoma (microwave ablation or transarterial chemoembolization) Written informed consent obtained Aged 18 to 80 years Performance status of 0 or 1 Preserved organ function Able to attend outpatient visits

Exclusion criteria

Exclusion criteria: Serious systemic infections or fever >= 38 degrees Celsius Pregnant, possibly pregnant, or breastfeeding women Psychiatric illness or symptoms interfering with participation Ongoing systemic steroid therapy Uncontrolled diabetes (HbA1c >= 8%) or hypertension Unstable angina or myocardial infarction within 6 months Interstitial pneumonia, pulmonary fibrosis, severe emphysema, or acute heart failure History of cerebrovascular disease within 6 months Any condition deemed inappropriate by the attending physician

Design outcomes

Primary

Measure	Time frame
Proportion of weeks during the 12-week intervention period in which participants performed strength training at least 3 days per week and achieved the step count target on at least 5 days per week	—

Secondary

Measure	Time frame
Number of feasibility-limiting events during the 12-week intervention period Reasons for withdrawal or dropout (based on a termination survey at the end of the 12-week period) Completion and collection rate of the exercise diary from discharge to week 12 Changes in vital signs before and after the 12-week intervention Changes in grip strength and 6-minute walk distance from baseline to week 12 Changes in quality of life assessed by the Chronic Liver Disease Questionnaire (CLDQ) from baseline to week 12	—

Measure

Time frame

Number of feasibility-limiting events during the 12-week intervention period Reasons for withdrawal or dropout (based on a termination survey at the end of the 12-week period) Completion and collection rate of the exercise diary from discharge to week 12 Changes in vital signs before and after the 12-week intervention Changes in grip strength and 6-minute walk distance from baseline to week 12 Changes in quality of life assessed by the Chronic Liver Disease Questionnaire (CLDQ) from baseline to week 12

—

Countries

Japan

Contacts

Public ContactMichiyuki Kawakami

Keio University School of Medicine Department of Rehabilitation Medicine

michiyukikawakami@hotmail.com03-5363-3833

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026