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Comparison Efficacy of Cefmetazole or Flomoxef Versus Carbapenem Antibiotics for ESBL-Producing Enterobacterales Bacteremia: A Systematic Review and Meta-Analysis

Comparison Efficacy of Cefmetazole or Flomoxef Versus Carbapenem Antibiotics for ESBL-Producing Enterobacterales Bacteremia: A Systematic Review and Meta-Analysis - Comparison Efficacy of Cefmetazole or Flomoxef Versus Carbapenem Antibiotics for ESBL-Producing Enterobacterales Bacteremia: A Systematic Review and Meta-Analysis

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000058651
Enrollment
10
Registered
2025-07-31
Start date
2025-07-31
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales bacteremia

Interventions

None listed

Sponsors

Tohoku Medical and Pharmaceutical University and Tohoku Medical and Pharmaceutical University Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: We will conduct a literature search to compare 14 day or 30 day mortality, between cefmetazole or flomoxef and carbapenems for patients with ESBL-producing Enterobacterales bacteremia. Our search will be performed in the following databases: PubMed, Japanese Journal of Chemotherapy, Japanese Journal of Infection Prevention and Control, Ichushi-WEB, Cochrane Review, CINAHL, and Web of Science.

Exclusion criteria

Exclusion criteria: Under 18 years old,Pregnancy,Infections caused by ESBL producing Enterobacteriaceae without bacteremia,No information about 14 day or 30 day mortality,Studies for which the full text was not accessible

Design outcomes

Primary

MeasureTime frame
14 or 30 day-mortality rates—

Countries

Japan

Contacts

Public ContactHaruka Imai

Tohoku Medical and Pharmaceutical University and Tohoku Medical and Pharmaceutical University Hospit Division of Infectious Diseases and Infection Control, Faculty of Medicine

m05009hi@jichi.ac.jp0222591221

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026