A Multicenter Retrospective Study Comparing Radiosurgical Techniques for Large Brain Metastases Treated with Gamma Knife Radiosurgery (Japanese Leksell Gamma Knife Society 2501 Study)

A Multicenter Retrospective Study Comparing Radiosurgical Techniques for Large Brain Metastases Treated with Gamma Knife Radiosurgery (Japanese Leksell Gamma Knife Society 2501 Study) - JLGK2501

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000058644

Enrollment

300

Registered

2025-08-04

Start date

2025-07-24

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain metastases

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who underwent gamma knife radiosurgery for brain metastases with a tumor volume of 4 cm3 or more between January 1, 2016, and December 31, 2024, will be included

Exclusion criteria

Exclusion criteria: The patient has previously undergone other treatments or interventions for brain metastases, such as surgical resection, cyst drainage, or whole-brain radiotherapy. Karnofsky Performance Status (KPS) is below 70% (if neurological symptoms caused by brain metastases are present, the pre-symptom KPS is below 70%). The number of brain metastases exceeds 10. Contrast-enhanced MRI was not obtained for treatment planning. There is evidence of cerebrospinal fluid dissemination. No post-treatment contrast-enhanced MRI has been obtained, or post-treatment imaging status is unknown. The primary tumor is classified as carcinoma of unknown origin, sarcoma, or lymphoma.

Design outcomes

Primary

Measure	Time frame
CNS index lesion progression-free survival	—

Countries

Japan

Contacts

Public ContactMariko Kawashima

NTT Medical Center Tokyo Gamma Knife Center

mariko.furi@gmail.com0334486111

Outcome results