Relationships of variations in the oral microbiota and patients with medication-related osteonecrosis of the jaw

Relationships of variations in the oral microbiota and patients with medication-related osteonecrosis of the jaw - Relationships of variations in the oral microbiota and patients with MRONJ

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000058621

Enrollment

200

Registered

2025-08-01

Start date

2025-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Medication-related osteonecrosis of the jaw

Interventions

In a single-arm study, a single sample of saliva is collected from MRONJ patients.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients diagnosed with MRONJ who are at least 18 years of age

Exclusion criteria

Exclusion criteria: Patients under 18 years of age and without sufficient judgment

Design outcomes

Primary

Measure	Time frame
Extract DNA from saliva of MRONJ patients and perform a comprehensive analysis of bacterial species. Bacterial species are clustered and analyzed for trends in balance abnormalities specific to MRONJ patients.	—

Countries

Japan

Contacts

Public ContactKento Kaminogo

Nagoya University Hospital Department of Oral and Maxillofacial Surgery

kaminogo.kento.r3@f.mail.nagoya-u.ac.jp0527442348

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026