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A retrospective study to evaluate the tolerability of outpatient initiation of platinum-based combination therapy with carboplatin

A retrospective study to evaluate the tolerability of outpatient initiation of platinum-based combination therapy with carboplatin - A retrospective study on the safety of carboplatin-based chemotherapy initiation in outpatient settings

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000058600
Enrollment
400
Registered
2025-07-25
Start date
2024-09-26
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-small cell lung cancer

Interventions

None listed

Sponsors

Chiba University Hospital
Lead Sponsor
Funabashi Municipal Medical Center, Chiba Cancer Center Research Institute
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Eligible cases are those who meet either (1) or (2) below and also meet (3). (1) Patients with advanced or recurrent non-small cell lung cancer with a performance status (PS) of 0-1 who have started initial systemic chemotherapy with a regimen containing carboplatin. (2) Patients with advanced or recurrent non-small cell lung cancer with a PS of 0-1 who have started initial systemic chemotherapy with a regimen containing carboplatin after molecular targeted drug therapy. (3) Patients who started initial treatment between January 1, 2019 and December 31, 2022.

Exclusion criteria

Exclusion criteria: Patients who meet any of the following criteria will be excluded. Those who have expressed refusal to participate in this study through a disclosure document. Cases in which initial systemic chemotherapy was administered after unplanned emergency hospitalization. Those treated with the Atezolizumab+Bevacizumab+Carboplatin+Paclitaxel (ABCP) regimen (In reality, it takes more than 5-6 hours to administer the drugs, making it difficult to administer the regimen in an outpatient chemotherapy room. Therefore, it is not possible to compare the outpatient and inpatient groups.)

Design outcomes

Primary

MeasureTime frame
Completion rate of 4 chemotherapy courses

Secondary

MeasureTime frame
Unscheduled medical visit rate up to 4 cycles, Adverse events of grade 3 or higher, Progression-free survival, Overall survival, Dose reduction rate during 4 cycles of treatment

Countries

Japan

Contacts

Public ContactFujihiro Kure

Chiba University Hospital Department of Respiratory medicine

23fd0146@student.gs.chiba-u.jp043-222-7171

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026