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Prospective observational study on the relationship between action potentials emitted by the diaphragm during ventilatory management and the possibility of extubation

Prospective observational study on the relationship between diaphragmatic action potentials and extubation outcomes during ventilatory management - diaphragmatic action potential test

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000058595
Enrollment
80
Registered
2025-07-25
Start date
2025-06-24
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory failure requiring ventilator management in the intensive care unit

Interventions

None listed

Sponsors

Nara Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. 18 years of age or older 2. Patients who started ventilator management by oral intubation 3. Cases in which muscle relaxants are administered at the start of ventilation 4.Can be managed in Assist/Control Mode 5. Ventilated with Puritan Bennett980/840, SERVO-U Ventilator, Hamilton C6 6.Patients expected to survive more than 24 hours

Exclusion criteria

Exclusion criteria: 1. patients who were intubated upon ICU admission 2. pregnant women 3. patients whose diaphragmatic function is not expected to recover (e.g., end-stage neuromuscular disease) 4. Artificial respiration for more than 8 hours prior to admission to the ICU 5. patients who have been in the ICU within the past month 6. patients who have undergone invasive positive pressure ventilation for non-surgical reasons within the past month 7. whose Code is DNAR 8. lack of equipment such as Servo series, NAVA Catheter, etc. 8. 9. absence of investigator 10. failure to obtain research consent 11. drug intoxication 12. brain death

Design outcomes

Primary

MeasureTime frame
Evaluate the relationship between the Edi from intubation to extubation and the VFD28.

Secondary

MeasureTime frame
Relationship between UAB (unassisted breathing) and Edi at 30 days, and mortality and Edi at 30 days

Countries

Japan

Contacts

Public ContactYUSUKE NAITO

Nara Medical University Department of Anesthesiology

schneider.yusuke@gmail.com0744-22-3051

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026