Association between medication adherence and trust and satisfaction with health care providers in patients with hypertension, diabetes, and dyslipidemia (THRIVE): a multi-center, prospective, observational study.

Association between medication adherence and trust and satisfaction with health care providers in patients with hypertension, diabetes, and dyslipidemia (THRIVE): a multi-center, prospective, observational study. - THRIVE study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000058581

Enrollment

750

Registered

2025-08-01

Start date

2025-08-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypertension, diabetes, dyslipidemia

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Individuals aged 18 years or older 2. Patients who visit a community pharmacy and receive a prescription for themselves 3. Patients currently receiving pharmacological treatment (at least one active agent) for hypertension, diabetes, or dyslipidemia (any one or more of these conditions), and whose treatment includes a dose increase or the addition of a new medication 4. Patients who have provided written informed consent

Exclusion criteria

Exclusion criteria: 1. Individuals with cognitive impairments that make it difficult to complete patient-reported outcome (PRO) questionnaires 2. Individuals with mental health conditions that make it difficult to complete PRO questionnaires 3. Individuals whose native language is not Japanese

Design outcomes

Primary

Measure	Time frame
The mean scores and 95% confidence intervals for the Adjusted Necessity Score (ANS), Adjusted Concern Scale (ACS), and the Necessity-Concern Differential (NCD) will be calculated and presented graphically for patients with hypertension, diabetes, and dyslipidemia.	—

Secondary

Measure	Time frame
The mean scores and 95% confidence intervals for the FACIT-Satisfaction with Pharmacist (FACITSWiP) and the short version of the Wake Forest Physician Trust Scale (WFPTS) will be calculated and presented graphically for patients with chronic metabolic diseases (hypertension, diabetes, and dyslipidemia). To evaluate the relationship between satisfaction with pharmacists and trust in physicians, a scatter plot will be created using the FACIT-SWiP and WFPTS scores. The correlation coefficient and its 95% confidence interval will also be calculated. The proportions of patients who experienced dose increases or additions of prescribed medications will be calculated at 6 months and 12 months, treating these as events. Time to dose increase or addition of prescribed medications will be analyzed using the Kaplan-Meier method. Group comparisons based on baseline variables will be conducted using the log-rank test. Additionally, hazard ratios (HRs) and 95% confidence intervals (CIs) will be estimated using the Cox proportional hazards model to evaluate differences between groups.	—

Measure

Time frame

The mean scores and 95% confidence intervals for the FACIT-Satisfaction with Pharmacist (FACITSWiP) and the short version of the Wake Forest Physician Trust Scale (WFPTS) will be calculated and presented graphically for patients with chronic metabolic diseases (hypertension, diabetes, and dyslipidemia). To evaluate the relationship between satisfaction with pharmacists and trust in physicians, a scatter plot will be created using the FACIT-SWiP and WFPTS scores. The correlation coefficient and its 95% confidence interval will also be calculated. The proportions of patients who experienced dose increases or additions of prescribed medications will be calculated at 6 months and 12 months, treating these as events. Time to dose increase or addition of prescribed medications will be analyzed using the Kaplan-Meier method. Group comparisons based on baseline variables will be conducted using the log-rank test. Additionally, hazard ratios (HRs) and 95% confidence intervals (CIs) will be estimated using the Cox proportional hazards model to evaluate differences between groups.

—

Countries

Japan

Contacts

Public ContactRyohei Soeishi

Tokyo University of Pharmacy and Life Sciences Department of Clinical Assessment

ryohei-soeishi@pharma802.com042-676-5111

Outcome results