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Evaluation of the Effectiveness of Non-Pharmacological Interventions for Improving Apathy after Stroke

Randomized Controlled Trial Comparing the Effects of Cognitive Training, Physical Exercise, and Behavioral Therapy on Apathy in Post-Stroke Patients - Apathy Post-stroke: Physical Exercise, cognitive training, And behavioral therapy for Life improvement

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000058477
Enrollment
60
Registered
2025-08-01
Start date
2025-08-01
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-stroke apathy

Interventions

Cognitive training will be provided for 40 minutes per day, 5 days per week, for 2 weeks (total 10 sessions). Training includes visual scanning tasks, verbal fluency tasks, and constructional tasks. T

Sponsors

Kawasaki University of Medical Welfare
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Ability to provide written informed consent, Aged between 18 and 79 years, Right-handed, MMSE score of 23 or higher, AES score of 37 or higher, Diagnosed with post-stroke apathy within 3 months after stroke onset

Exclusion criteria

Exclusion criteria: Patients with severe systemic diseases that hinder participation in rehabilitation, or with psychosis, depression, disturbance of consciousness, or hearing or visual impairments that interfere with assessment.

Design outcomes

Primary

MeasureTime frame
Outcome measure: Subjective apathy assessment (Apathy Evaluation Scale: AES) Assessment time points: Before intervention (Day 1) and after intervention (Day 14)

Secondary

MeasureTime frame
Assessment time points: Before intervention (Day 1) and after intervention (Day 14) Outcome measures: Cognitive function (Mini-Mental State Examination: MMSE), Motor function (Fugl-Meyer Motor Assessment), Emotional function (Hamilton Depression Rating Scale: Ham-D), Activities of daily living (Functional Independence Measure: FIM) Assessment time point: Before intervention (Day 1) Outcome measures: Brain imaging (lesion location assessed by MRI/CT), Demographic and medical data (age, sex, medical history, comorbidities, medication status)

Countries

Japan

Contacts

Public ContactKazuyuki Matsuoka

Graduate School, Kawasaki University of Medical Welfare Graduate School of Health Sciences, Department of Sensory Rehabilitation

hhrgw67606@yahoo.co.jp086-462-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Sep 19, 2026