Efficacy of Dual Antiplatelet Therapy Including P2Y12 Inhibitor Loading in Preventing Motor Function Deterioration in the Acute Phase of Noncardioembolic Ischemic Stroke

A Prospective Study to Evaluate the Preventive Effect of Dual Antiplatelet Therapy Including P2Y12 Inhibitor Loading on Early Motor Deterioration in Acute Noncardioembolic Ischemic Stroke - A Prospective Study on the Prevention of Motor Function Deterioration with DAPT Including P2Y12 Inhibitor Loading in Acute Noncardioembolic Ischemic Stroke

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000058468

Enrollment

200

Registered

2025-07-20

Start date

2023-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Noncardioembolic Ischemic Stroke

Interventions

Patients receiving dual antiplatelet therapy including P2Y12 inhibitor loading Patients receiving other antiplatelet therapies

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: -Age: 20 to 85 years -Able to start antiplatelet therapy within 48 hours of onset -Diagnosed with non-cardioembolic ischemic stroke

Exclusion criteria

Exclusion criteria: -Cardioembolic stroke -Atherothrombotic cerebral infarction -Stroke of undetermined embolic source -Patients with bleeding diathesis -Patients contraindicated for antiplatelet therapy -Patients for whom motor function assessment is difficult (including higher brain dysfunction and consciousness disturbance)

Design outcomes

Primary

Measure	Time frame
Worsening of motor NIHSS by 1 point or more at 7 days after treatment initiation	—

Secondary

Measure	Time frame
1. Worsening of motor NIHSS by 1 point or more at 21 days after treatment initiation 2. Modified Rankin Scale at 21 days after treatment initiation	—

Countries

Japan

Contacts

Public ContactTakashi Mizowaki

Junshin Hospital Clinical Research Department Clinical Neurosurgery Research Department

njapxblj@gmail.com079-437-3555

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Sep 16, 2026