Preventive Effect of Intraoral Cooling on Taste Dysfunction in Early Breast Cancer Patients Receiving Adjuvant Chemotherapy: A Pilot Study

Preventive Effect of Intraoral Cooling on Taste Dysfunction in Early Breast Cancer Patients Receiving Adjuvant Chemotherapy: A Pilot Study - Preventive Effect of Intraoral Cooling on Taste Dysfunction in Early Breast Cancer Patients Receiving Adjuvant Chemotherapy: A Pilot Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000058454

Enrollment

Registered

2025-07-17

Start date

2025-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

breast cancer

Interventions

Ice chips or ice water usual care

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients aged 20 years or older 2. Patients with histologically confirmed primary breast cancer 3. Patients scheduled to receive any of the following as adjuvant therapy for early-stage breast cancer: ??????-Dose-dense doxorubicin + cyclophosphamide (AC) / epirubicin + cyclophosphamide (EC) with or without docetaxel (DTX) or paclitaxel (PTX) ??????-Docetaxel + cyclophosphamide (TC) ??????-Trastuzumab + paclitaxel (HT) ??????-Trastuzumab + docetaxel (HDTX) ??????-As neoadjuvant therapy: pembrolizumab (Pembro), PTX, and carboplatin (CBDCA), followed by Pembro + AC or EC 4. Patients without taste dysfunction 5. Patients capable of using electronic devices 6. Patients who can provide written informed consent of their own free will

Exclusion criteria

Exclusion criteria: 1. Determined by the attending physician to be inappropriate for inclusion in the study.

Design outcomes

Primary

Measure	Time frame
Incidence of taste dysfunction based on patient-reported outcomes	—

Countries

Japan

Contacts

Public ContactTakayuki Iwamoto

Kawasaki Medical School Breast and Thyroid Surgery

tiwamoto@med.kawasaki-m.ac.jp+81-86-462-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026