Individuals who undergo third molar extraction under sedation management at the Department of Dental Anesthesiology, Hokkaido University Hospital between the date of study approval and March 31, 2026, and who are hospitalized postoperatively.
Conditions
Interventions
None listed
Sponsors
Hokkaido University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1 Individuals aged 18 years or older at the time of consent. 2 Individuals classified as ASA Physical Status 1 or 2. 3 Individuals with a BMI between 18.5 and 25. 4 Individuals scheduled to undergo third molar extraction under intravenous sedation, with an expected surgical duration of more than 30 minutes. 5 Individuals scheduled to receive 2% lidocaine with epinephrine as the local anesthetic during infiltration anesthesia. 6 Individuals scheduled to be managed under intravenous sedation using either dexmedetomidine or propofol. 7 Individuals scheduled to receive intravenous flurbiprofen axetil at the end of anesthesia as postoperative analgesia. 8 Individuals who have received a full explanation of the study, fully understood its content, and provided written informed consent of their own free will.
Exclusion criteria
Exclusion criteria: 1 Individuals taking steroids or immunosuppressive agents at the time of the preoperative examination. 2 Individuals with a maximal mouth opening of three fingerbreadths or less. 3 Individuals deemed unsuitable for participation in the study by the principal investigator for any other reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Temporal changes in the High Frequency Variability Index (HFVI) and comparison between dexmedetomidine and propofol | — |
Countries
Japan
Contacts
Public ContactYukie Nitta
Hokkaido University Hospital Dental Anesthesiology
Outcome results
None listed