Research on the long-term effects of renal damage in preeclampsia and the risk of future chronic kidney disease

Study on the long-term effects of renal damage in preeclampsia using serum hyaluronan, urinary podocalyxin, liver-type fatty acid-binding protein, and N-acetyl-beta-D-glucosaminidase measurements - Study on the long-term effects of renal damage in preeclampsia based on serum and urine marker measurements

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000058351

Enrollment

150

Registered

2025-07-07

Start date

2025-07-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preeclampsia

Interventions

None listed

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: This retrospective cohort study included preeclampsia (PE) women and normal pregnant women who delivered at Aichi Medical University Hospital between January 2022 and December 2024. PE is defined as hypertension developing after 20 weeks of gestation, accompanied by proteinuria.

Exclusion criteria

Exclusion criteria: Participants with multiple pregnancies, glucose metabolism disorders, renal complications, or systemic lupus erythematosus, two groups were identified for analysis are excluded.

Design outcomes

Primary

Measure	Time frame
Serum hyaluronan (glycocalyx injury), urinary podocalyxin (podocyte injury), urinary liver-type fatty acid-binding protein (L-FABP) and N-acetyl-beta-D-glucosaminidase (NAG) (tubular injury) were measured at PE diagnosis and at 12 weeks postpartum.	—

Countries

Japan

Contacts

Public ContactKazumasa Sugiura

Aichi Medical University Department of Obstetrics and Gynecology

sugiura.kazumasa.489@mail.aichi-med-u.ac.jp0561623311

Outcome results