adult asthma
Conditions
Interventions
withdrawing LAMA from ICS/LABA/LAMA therapy
Sponsors
Yamanashi Red Cross Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients attending the outpatient internal medicine clinic of Yamanashi Red Cross Hospital between August 1, 2025, and July 31, 2026, will be screened. Eligible patients are those aged 18 years or older who have been diagnosed with asthma according to the 2024 Asthma Prevention and Management Guidelines, and who meet all of the following criteria within 28 days prior to Visit 1, with the ability to provide written informed consent: 1 Have been receiving ICS/LABA/LAMA therapy for at least 6 months 2 Have an Asthma Control Test (ACT) score >2 3 Have had no asthma exacerbation in the past year (regardless of severity), defined as any of the following: treatment with oral or systemic corticosteroids, emergency department visits, or hospitalization 4 Have had no use of oral corticosteroids as maintenance therapy within the past year
Exclusion criteria
Exclusion criteria: 1 asthma COPD overlap diagnosed according to the Guidelines for the Diagnosis and Treatment of Asthma COPD Overlap 2nd edition 2 Cough variant asthma 3 Unable to provide written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rate of asthma exacerbations | — |
Secondary
| Measure | Time frame |
|---|---|
| Median time to asthma exacerbation Change from baseline in FEV1 and FEV1 predicted Change from baseline in ACT score Change from baseline in FeNO Change from baseline in blood eosinophil count Univariate analysis of baseline characteristics between patients with and without asthma exacerbation Univariate analysis of the association between asthma exacerbation and checklist items related to airway hyperresponsiveness | — |
Countries
Japan
Contacts
Public ContactYosuke Fukuda
Yamanshi Red Cross Hospital Department of Medicine, Division of Respiratory Medicine
Outcome results
None listed