Investigation of Cellular, Humoral, and Memory Immune Responses to COVID-19 Vaccination in Dialysis Patients

Investigation of Cellular, Humoral, and Memory Immune Responses to COVID-19 Vaccination in Dialysis Patients - Investigation of Cellular, Humoral, and Memory Immune Responses to COVID-19 Vaccination in Dialysis Patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000058246

Enrollment

336

Registered

2025-06-22

Start date

2021-11-30

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19, hemodialysis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: [Dialysis Patients] Individuals receiving hemodialysis or peritoneal dialysis at participating institutions or affiliated facilities who have received two doses of a COVID-19 vaccine (either Pfizer or Moderna). [Non-Dialysis Patients] Staff members of Saiseikai Central Hospital in Tokyo or its affiliated facilities (Konan no Sato), their family members or acquaintances, or outpatients regularly seen at Saiseikai Central Hospital, who have received two doses of a COVID-19 vaccine (either Pfizer or Moderna).

Exclusion criteria

Exclusion criteria: Individuals with a history of malignancy treatment within the past year or those receiving steroids or immunosuppressive agents will be excluded. In the non-dialysis group, individuals with an eGFR of 45 mL/min/1.73 m2 or lower, or those diagnosed with nephrotic syndrome, will also be excluded.

Design outcomes

Primary

Measure	Time frame
SARS-CoV-2 IgG antibody titers, cellular immunity, humoral immunity, and memory cells will be compared between 6 months after the primary vaccination and 1 month after the booster vaccination.	—

Countries

Japan

Contacts

Public ContactAyumi Yoshifuji

Tokyo Saiseikai Central Hospital Nephrology

jsdt.vaccine.antibody@gmail.com+81-3-3451-8211

Outcome results