A study on the evaluation of consciousness disorders in patients with acute drug poisoning using an automatic pupil measurement device

Evaluation of the usefulness of an automatic pupil measurement device for diagnosing consciousness disorders in patients with acute drug poisoning: A single-center prospective observational study - Automated Detection of Awareness in Poisoned Toxicology patients: ADAPT STUDY

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000058237

Enrollment

Registered

2025-06-21

Start date

2025-06-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Drug Intoxication

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Cases diagnosed with acute drug poisoning or strongly suspected of acute drug poisoning who visited the emergency department.

Exclusion criteria

Exclusion criteria: Individuals under the age of 18 Individuals who did not consent to participate in the study Cases where pupil response measurement was difficult for any reason (e.g., history of surgery, trauma, etc.) Cases with obvious central nervous system disorders (e.g., cerebral hemorrhage, cerebral infarction, epilepsy, etc.) Cases where pupil measurement using an automatic pupil measurement device was not performed prior to discharge or return home Cases where consent to participate in the study was withdrawn In cases of unexpected adverse events

Design outcomes

Primary

Measure	Time frame
Pupil response index measured by an automatic pupil measurement device	—

Secondary

Measure	Time frame
Consciousness impairment (Glasgow Coma Scale, JCS: Japan Coma Scale) Correlation coefficient between pupil response indicators and Glasgow Coma Scale, Japan Coma Scale Pupil diameter Speed of light reflex Oxygen administration Presence of tongue base depression Outcome (hospitalization, discharge, transfer, return home) Length of stay in the intensive care unit SOFA score Types of medications administered, etc.	—

Measure

Time frame

Consciousness impairment (Glasgow Coma Scale, JCS: Japan Coma Scale) Correlation coefficient between pupil response indicators and Glasgow Coma Scale, Japan Coma Scale Pupil diameter Speed of light reflex Oxygen administration Presence of tongue base depression Outcome (hospitalization, discharge, transfer, return home) Length of stay in the intensive care unit SOFA score Types of medications administered, etc.

—

Countries

Japan

Contacts

Public ContactRYUTO YOKOYAMA

Yamagata University School of Medicine Department of Emergency and Critical Care Medicine

ryusi0311@gmail.com0236285422

Outcome results