Healthy adults
Conditions
Interventions
Have participants smell the test product for 1 minute
Apply the test product to their face with their hands for 1 minute
Have participants wipe with the test product for 1 minute
Sponsors
KOBAYASHI Pharmaceutical Co., Ltd.
Otemon Gakuin Educational Foundation
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1) Healthy female university students aged 18 or older who suffer from acne 2) Non-smokers 3) Not receiving medical treatment for hypertension, diabetes, mental illness, sleep disorders, or serious illnesses 4) Participants who have received an explanation of the study, fully understood the contents, and provided their own informed consent
Exclusion criteria
Exclusion criteria: 1) Heavy alcohol drinkers (average alcohol intake of 60g or more per day) 2) Individuals who have undergone hormone replacement therapy or are taking oral contraceptives within the past year 3) Individuals who are using drugs that affect the secretion of cortisol (steroids, phenytoin, phenobarbital) 4) Individuals with extremely irregular eating habits, or those with irregular lifestyles such as shift workers or night shift workers 5) Individuals taking foods for specified health uses, foods with functional claims, health foods (including supplements), etc. that take into consideration their effects on the autonomic nervous system and sleep 6) Individuals with blocked noses due to hay fever or other conditions that make it difficult to distinguish between different scents 7) Individuals who are allergic to the test products 8) Individuals who prefer fragrance-free products, or those who dislike the scent of the test product. 9) Individuals who are pregnant, wish to become pregnant, or are breastfeeding. 10) Individuals with irregular menstrual cycles (average menstrual cycle of 24 days or less, or 39 days or more). 11) Individuals who are regularly visiting a clinic for acne treatment. 12) Individuals with atopic skin. 13) Individuals who have previously experienced abnormal skin reactions such as redness, swelling, itching, irritation, discoloration (e.g., vitiligo), or hyperpigmentation after using cosmetic products containing ethanol, isopropylmethylphenol, or dipotassium glycyrrhizate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in salivary stress markers/indicators due to the use of the test product. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in psychological stress induced by the test product. Changes in heart rate and brain waves due to the use of the test product. Questionnaire regarding skin condition and stress level prior to measurement. | — |
Countries
Japan
Contacts
Public ContactShuu Imai
KOBAYASHI Pharmaceutical Co., Ltd. Life Science Research Department R&D Headquarters
Outcome results
None listed