Familial Hypercholesterolemia
Conditions
Interventions
None listed
Sponsors
Juntendo University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Individuals with record linkage between medical claims data (including diagnoses such as hypertension, diabetes, and dyslipidemia, as well as prescriptions and procedures) and specific health checkup data, in whom at least one LDL-C measurement is available in the health checkup records between April 1, 2010, and March 31, 2022. LDL-C levels >=250 mg/dL (HeFH threshold) or >=370 mg/dL (HoFH threshold) recorded at least once during the study period Age between 40 and 75 years at the time of the first qualifying LDL-C record
Exclusion criteria
Exclusion criteria: Individuals with a documented history of coronary heart disease (CHD) at baseline or at the start of follow-up (excluded from the main cohort but retained in restricted cubic spline and sensitivity analyses). Individuals with implausible or erroneous LDL-C measurements (e.g., >=999 mg/dL).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of major adverse cardiovascular events (Modified MACE), defined as: - Non-fatal myocardial infarction - Non-fatal ischemic stroke - Coronary revascularization procedures including PCI and CABG | — |
Secondary
| Measure | Time frame |
|---|---|
| - Lipid-lowering medication patterns (e.g., statins, PCSK9 inhibitors) - Cardiovascular-related rehospitalization - Healthcare resource utilization (e.g., total hospital days, costs) | — |
Countries
Japan
Contacts
Public ContactKeiko Goto
Juntendo University Clinical genetics
Outcome results
None listed