A cross-sectional study comparing serum proinsulin levels in diabetes (type 1 subtypes and type 2) and healthy controls.

Cross-sectional comparison of serum proinsulin levels by diabetes subtype and disease duration. - Proinsulin-CS (OMPU)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000058111

Enrollment

100

Registered

2025-06-08

Start date

2025-10-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute-onset type 1 diabetes, fulminant type 1 diabetes, slowly progressive type 1 diabetes, type 2 diabetes (plus healthy controls))

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Outpatients or inpatients at the hospital, or healthy controls (2) Aged >=16 and <100 years at enrollment (3) Written informed consent has been obtained (including consent from a legally acceptable representative when applicable)

Exclusion criteria

Exclusion criteria: (1) Onset time of diabetes is not documented in the medical record (2) Diagnosed with pancreatic cancer (3) History of pancreatectomy (4) Blood glucose <70 mg/dL in the collected sample

Design outcomes

Primary

Measure	Time frame
proinsulin	—

Secondary

Measure	Time frame
Blood glucose, C-peptide, insulin, islet-associated autoantibodies (GAD Ab, IA-2 Ab, insulin Ab, ZnT8 Ab), TSH, FT4, pancreatic exocrine enzyme (amylase)	—

Countries

Japan

Contacts

Public ContactShohei Kato

Osaka Medical and Pharmaceutical University Department of Internal Medicine 1

naika1hp@ompu.ac.jp072-683-1221

Outcome results