A nationwide multi-institutional retrospective study to investigate predictors of positive peritoneal cytology in pancreatic Cancer -A project study of Japan Pancreas Society-

A nationwide multi-institutional retrospective study to investigate predictors of positive peritoneal cytology in pancreatic Cancer - CYCLONE study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000058081

Enrollment

5000

Registered

2025-10-10

Start date

2025-10-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreatic cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients with pancreatic cancer who have histologically or cytologically confirmed adenocarcinoma or adenosquamous carcinoma prior to performing peritonial cytology. 2) Cases in which resectability classification is diagnosed prior to performing peritonial cytology. 3) Cases in which preoperative treatment (chemotherapy, radiation therapy, or combined chemoradiotherapy) has not been introduced prior to performing peritonial cytology. 4) Patients meeting the above criteria who underwent peritonial cytology between January 1, 2017 and December 31, 2024, at the time of the review laparoscopy or at the time of radical resection without preoperative treatment.

Exclusion criteria

Exclusion criteria: 1) Cases with malignant tumors under treatment or diagnosed concurrently at the time of diagnosis of pancreatic cancer (*Endoscopically curatively resected intramucosal carcinoma or basal cell carcinoma or squamous cell carcinoma of the skin may be registered). 2) Cases of residual pancreatic cancer. 3) Cases diagnosed with resectability classification of UR-M before laparoscopy. 4) Cases who refused to participate in this study by opting out.

Design outcomes

Primary

Measure	Time frame
The primary endpoint is the percentage of positive cytology results per resectability category for pancreatic cancer among patients who underwent peritonial cytology.	—

Secondary

Measure	Time frame
Predictors of positive peritonial cytology. Factors involved in the negative results of positive peritonial cytology. Recurrence-free survival rate, cumulative recurrence rate, overall survival rate, site of recurrence, and form of recurrence after resection of the primary tumor.	—

Countries

Japan

Contacts

Public ContactAyaka Itoh

University of Toyama Department of Surgery and Science, Faculty of Medicine, Academic Assembly

aitoh@med.u-toyama.ac.jp076-434-7331

Outcome results