Assessment of Oocyte aging Using Aging-Associated Chemokine Expression (CXCL5 and CXCR2) in Cumulus Cells

Study on the Diagnosis of Oocyte Aging Using Discarded Cumulus Cells from the Assisted Reproductive Technology Process of In Vitro Fertilization - Diagnostic Test for Oocyte Aging Based on CXCL5 Measurement

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000058078

Enrollment

600

Registered

2025-06-07

Start date

2021-10-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Advanced-Age Infertility Patients Requiring In Vitro Fertilization

Interventions

None listed

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Patients who have provided written informed consent of their own free will after receiving a thorough explanation of the study and fully understanding its contents. Eligible participants are women aged 35 to 48 years who are scheduled to undergo intracytoplasmic sperm injection (ICSI) and have agreed to provide cumulus cells collected at the time of oocyte retrieval.

Exclusion criteria

Exclusion criteria: Patients who have not provided written informed consent, unmarried female patients, and those deemed inappropriate for inclusion in the study by the attending physician.

Design outcomes

Primary

Measure	Time frame
Association between CXCL5 and CXCR2 expression levels in cumulus cells and oocyte developmental outcomes (fertilization rate, blastocyst formation rate, pregnancy outcomes, poregnancy rate, choromosome normality).	—

Secondary

Measure	Time frame
Secondary outcomes include the correlation between CXCL5 and CXCR2 expression levels and patient age, embryo morphological evaluation, ovarian stimulation protocols, and causes of infertility.	—

Countries

Japan

Contacts

Public ContactKazuhiro Kawamura

Juntendo University Department of Obstetrics and Gynecology

k.kawamura.aq@juntendo.ac.jp03-3813-3111

Outcome results