Correlations between Amyloid-beta Peptide Levels in Aqueous Humor and Visual Function in Glaucoma Patients

Correlations between Amyloid-beta Peptide Levels in Aqueous Humor, Retinal Thickness, and Visual Field Loss in Glaucoma Patients - Correlations between Amyloid-beta Levels and Visual Function

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000058049

Enrollment

600

Registered

2025-06-02

Start date

2022-10-12

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cataract / Glaucoma / Pseudoexfoliation syndrome / Exfoliation glaucoma

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients diagnosed with cataract, glaucoma, pseudoexfoliation syndrome, or exfoliation glaucoma and undergoing cataract or glaucoma surgery

Exclusion criteria

Exclusion criteria: The patient and/or his/her substitute decision-maker do not provide informed consent for participation in this study, or the patient's ophthalmologist decides not to allow the patient to participate in this study based on the patient's ocular condition.

Design outcomes

Primary

Measure	Time frame
Amyloid-beta 1-40 and Amyloid-beta 1-42 concentrations in the aqueous humor collected at the start of cataract or glaucoma surgery and measured using Sensitive and specific enzyme-linked immunosorbent assay (ELISA)	—

Secondary

Measure	Time frame
Correlations between Amyloid-beta 1-40 and Amyloid-beta 1-42 concentrations and retinal nerve fiber layer thickness and degree of visual field loss	—

Countries

Japan

Contacts

Public ContactTsutomu Ohashi

Ohashi Eye Center President

ohashi@rainbow.ne.jp0118644656

Outcome results