The Effects of Transcutaneous Auricular Vagus Nerve Stimulation on SEP and PPI

The Effects of Transcutaneous Auricular Vagus Nerve Stimulation on SEP and PPI - The Effects of Transcutaneous Auricular Vagus Nerve Stimulation on SEP and PPI

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000057997

Enrollment

Registered

2025-05-28

Start date

2025-05-28

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic pain syndrome

Interventions

Administer a single 15-minute session of transcutaneous auricular vagus nerve stimulation (taVNS). sham

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Twenty healthy athletes and twenty athletes with chronic pain lasting more than three months from the Track and Field Club of Niigata University of Health and Welfare.

Exclusion criteria

Exclusion criteria: Athletes with skin disorders

Design outcomes

Primary

Measure	Time frame
The study will include 20 healthy athletes and 20 athletes with chronic pain as participants. In the experiment, participants will undergo transcutaneous auricular vagus nerve stimulation (taVNS), and somatosensory evoked potentials (SEP) and prepulse inhibition (PPI) will be measured before and after stimulation to examine the effects on inhibitory responses. Electrocardiography (ECG) and electroencephalography (EEG) will also be recorded to assess changes in heart rate, autonomic nervous system activity, and the effects on the brain. By administering taVNS to both athletes with chronic pain and healthy athletes and evaluating neural inhibition function before and after stimulation, this study aims to provide evidence regarding the effectiveness and potential of taVNS.	—

Measure

Time frame

The study will include 20 healthy athletes and 20 athletes with chronic pain as participants. In the experiment, participants will undergo transcutaneous auricular vagus nerve stimulation (taVNS), and somatosensory evoked potentials (SEP) and prepulse inhibition (PPI) will be measured before and after stimulation to examine the effects on inhibitory responses. Electrocardiography (ECG) and electroencephalography (EEG) will also be recorded to assess changes in heart rate, autonomic nervous system activity, and the effects on the brain. By administering taVNS to both athletes with chronic pain and healthy athletes and evaluating neural inhibition function before and after stimulation, this study aims to provide evidence regarding the effectiveness and potential of taVNS.

—

Countries

Japan

Contacts

Public ContactKouya Yamashiro

Niigata University of Health and Welfare Department of Health and Sports Sciences

yamashiro@nuhw.ac.jp025-257-4757

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026