None
Conditions
Interventions
Hold a solution containing food ingredients in the mouth twice a day, for 3 minutes each time, every day for 4 weeks.
Hold a placebo solution in the mouth twice a day, for 3 minutes each time, every
Sponsors
LION corporation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Males and females aged 25 to 64 years old 2.People who cannot recognize any of the second lowest concentrations in the taste test 3.People who have given informed consent to participate in the study of their own free will
Exclusion criteria
Exclusion criteria: 1.People diagnosed with or having a history of taste disorders 2.People who regularly use medications that can cause taste disorders or have taken them from two weeks before the test until the start of the test 3.People who regularly take medicines, supplements, or foods containing zinc that may improve taste, or have taken them from two weeks before the test until the start of the test 4.People who are currently smoking 5.People diagnosed with Sjogren's syndrome or dry mouth 6.People diagnosed with or having a history of Sjogren's syndrome or dry mouth 7.People with cerebral infarction, chronic ear infections, chronic runny nose, sinusitis, history of stomach surgery, chronic kidney disease, diabetes, or cancer 8.People receiving radiation therapy 9.People who are pregnant or might be pregnant 10.People with tongue problems or chronic tongue pain 11.People who cannot consume sucrose (sweet), sodium chloride (salty), citric acid (sour), or quinine (bitter) at all 12.People allergic to the test food ingredients or who get itchy or rashes from products with these ingredients 13.People allergic to quinine or who get itchy or rashes from foods with quinine 14.People who have had allergic reactions (including skin itchiness or rashes) or other issues from using dental products like toothpaste or mouthwash, or cosmetics 15.People who are sensitive or allergic to alcohol (like getting itchy or rashes) 16.People with tooth loss other than wisdom teeth, except when due to past orthodontic treatment or accidental injury 17.People wearing braces or other orthodontic devices 18.People with tongue piercings or tattoos 19.People with strict diets that favor or avoid certain foods (like Halal, vegan) 20.People taking part or planning to take part in other oral health or function studies 21.People considered unsuitable by the main researcher
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Taste evaluation after 4 weeks of intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Taste evaluation using VAS (Visual Analog Scale) Amount of tongue coating Salivary secretion volume during masticatory stimulation Blood pressure Questionnaire on taste and oral condition | — |
Countries
Japan
Contacts
Public ContactKei Kurita
Lion corporation Advanced oral health science research laboratories
Outcome results
None listed