Investigation of the pain-relieving effect of nitrous oxide on traumatic trigeminal neuropathic pain: a case series

Investigation of the pain-relieving effect of nitrous oxide on traumatic trigeminal neuropathic pain: a case series - Effects of nitrous oxide on traumatic trigeminal neuropathic pain: a case series

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000057957

Enrollment

Registered

2025-05-24

Start date

2024-05-30

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Trigeminal neuropathic pain

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients were eligible for inclusion if they met at least one of the following criteria: 1) Inadequate pain control despite optimal treatment with at least two classes of recommended pharmacological agents for neuropathic pain (including anticonvulsants and/or antidepressants), 2) Intolerance to standard pharmacological treatments due to adverse effects, 3) Contraindications to standard pharmacological treatments due to comorbidities, drug interactions, or other clinical factors.

Exclusion criteria

Exclusion criteria: Patients were excluded if they presented with any contraindications to nitrous oxide administration, and inability to provide informed consent.

Design outcomes

Primary

Measure	Time frame
Changes in pain intensity (numerical rating scale) of traumatic neuropathic pain before and after N2O administration.	—

Countries

Japan

Contacts

Public ContactHidetaka Kuroda

Kanagawa Dental University Department of Dental Anesthesiology

kuroda@kdu.ac.jp+81-46-822-8896

Outcome results