Biological Responses to High-Concentration Oxygen Inhalation

Biological Responses to High-Concentration Oxygen Inhalation - Hyperoxia response

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000057949

Enrollment

Registered

2025-10-30

Start date

2025-06-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy people

Interventions

After having breakfast: Exhaled breath condensate will be collected for 20 minutes starting at 8:40 a.m. From 9:00 a.m. to 11:00 a.m., subjects will inhale 40% oxygen for 120 minutes. During thi

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy men and women aged 20 to 40 years at the time of enrollment

Exclusion criteria

Exclusion criteria: Not currently taking any medications Not undergoing dental treatment Willing to refrain from alcohol consumption and strongly flavored foods such as garlic during the study period

Design outcomes

Primary

Measure	Time frame
This study focuses on metabolites contained in exhaled breath condensate, particularly sulfur-containing metabolites. Exhaled breath condensate will be collected from 10 individuals and promptly analyzed using mass spectrometry to quantify various metabolites and assess changes induced by a 120-minute exposure to 40% oxygen.	—

Countries

Japan

Contacts

Public ContactHozumi Motohashi

Tohoku University Graduate School of Meicine

hozumi.motohashi.a7@tohoku.ac.jp81-22-717-8089

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026