Relationship Between Biliary Stent Occlusion, Diet, Bile Acids and Gut Microbime in Malignant Distal Biliary Obstrution

Relationship Between Biliary Stent Occlusion, Diet, Bile Acids and Gut Microbime in Malignant Distal Biliary Obstrution - Relationship Between Biliary Stent Occlusion, Diet, Bile Acids and Gut Microbime in Malignant Distal Biliary Obstrution

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000057935

Enrollment

Registered

2025-05-22

Start date

2024-11-26

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreatic cancer, Biliary tract cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients aged >=20 years with pancreatic or biliary tract cancer who have malignant biliary stricture in the common bile duct to common hepatic duct 2. Patients requiring initial transpapillary endoscopic biliary drainage due to biliary obstruction

Exclusion criteria

Exclusion criteria: 1. Patients with duodenal stricture at or distal to the major papilla 2. Patients on multiple antithrombotic agents (oral, intravenous, or subcutaneous) where appropriate management per clinical guidelines for duodenal mucosal sampling is not feasible 3. Patients with coagulation disorders 4. Patients with definitive diagnosis of cholangitis according to Tokyo Guidelines 2018 5. Patients who received antibiotics within one month prior to ERCP 6. Patients deemed unsuitable for the study by the principal investigator

Design outcomes

Primary

Measure	Time frame
Association between biliary stent occlusion and bile acid composition, gut microbiota profile, and dietary patterns.	—

Countries

Japan

Contacts

Public ContactAkira Nakamura

Shinshu Universiy Department of Medicine, Division of Gastroenterology and Hepatology

m040063b@yahoo.co.jp+81-263-37-2634

Outcome results