Examination of demand valve opening and closing conditions for efficient hydrogen inhalation using a nasal cannula

Examination of demand valve opening and closing conditions for efficient hydrogen inhalation using a nasal cannula - Efficient hydrogen inhalation through a nasal cannula

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000057922

Enrollment

Registered

2025-05-20

Start date

2025-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy volunteers

Interventions

The study subjects will be asked to absorb approximately 2% hydrogen gas through a nasal cannula. A demand valve system will be used to supply hydrogen gas only when inhaling. The subjects will be ask

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Individuals who have received a sufficient explanation of this study and have given their voluntary written consent after fully understanding it.

Exclusion criteria

Exclusion criteria: People with underlying respiratory or circulatory diseases. People with a history of hyperventilation syndrome.

Design outcomes

Primary

Measure	Time frame
The subjects will be asked to breathe at a respiratory rate of 12 to 30, while blood oxygen saturation and the hydrogen concentration in the air around the nasal cavity and oral cavity will be measured, and the valve control conditions that enable efficient inhalation while minimizing hydrogen leakage will be explored. Venous blood samples will be taken from some of the subjects to measure blood hydrogen concentrations.	—

Measure

Time frame

The subjects will be asked to breathe at a respiratory rate of 12 to 30, while blood oxygen saturation and the hydrogen concentration in the air around the nasal cavity and oral cavity will be measured, and the valve control conditions that enable efficient inhalation while minimizing hydrogen leakage will be explored. Venous blood samples will be taken from some of the subjects to measure blood hydrogen concentrations.

—

Countries

Japan

Contacts

Public ContactTakeshi Yamamoto

Yamaguchi University Graduate School of Medicine, Department of Health Sciences Department of Clinical Labobatory Sciences

kenyama@yamaguychi-u.ac.jp0834-22-2834

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026