Chronic non-cancer pain
Conditions
Interventions
Common procedures for both intervention and control groups: 1. The internet-based cognitive behavioral therapy (iCBT) used in this study consists of eight sessions, conducted weekly or biweekly over
Sponsors
Keio University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged between 20 and 74 years. 2. Patients with chronic pain lasting for more than three months and with a pain intensity of 4 or higher on the Numerical Rating Scale (NRS). 3. Patients who have not responded to standard pharmacological treatment and nerve block therapy for at least two months. 4. Patients diagnosed with primary chronic pain through a multidisciplinary conference at Interdisciplinary Pain Center in our hospital. 5. Patients who can provide written informed consent based on their own free will.
Exclusion criteria
Exclusion criteria: 1. Patients who are eligible for surgical treatment. 2. Patients with a history of anomalies of the central nervous system 3. Patients with severe psychiatric disorders or having conditions such as epilepsy. 4. Patients with cognitive impairment. 5. Patients who do not have a device to access to internet web site. 6. Patients who are unable to undergo MRI (e.g., due to claustrophobia or presence of metal in the body). 7. Patients who are unable to complete all eight sessions within a four-month period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in patient self-reported pain intensity measured by the Visual Analogue Scale (VAS, 0 - 100) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Changes in psychological state and pain-related physical impairment 2. Changes in electroencephalogram (EEG) and functional Magnetic Resonance Imaging (fMRI) 3. Changes in exosomes | — |
Countries
Japan
Contacts
Public ContactMorihiko Kawate
Keio University School of Medicine Department of Anesthesiology
Outcome results
None listed