An MRI study on the relationship between skill training and GABA Concentration

The role of skill training in the relationship between the globus pallidal volume and GABA concentration: A cross-sectional multimodal MRI study - Skill training and the globus pallidal GABA-volume relationship

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000057897

Enrollment

Registered

2025-05-26

Start date

2025-05-26

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy subjects

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Individuals who were 18 years of age or older at the time of obtaining consent (2) No history of psychiatric disorders

Exclusion criteria

Exclusion criteria: (1) Substance-related disorders within the past 6 months (2) Contraindications to undergoing MRS, such as metallic implants, pacemakers, or claustrophobia (3) Severe or unstable physical illness

Design outcomes

Primary

Measure	Time frame
Globus pallidal volume measured by MRI and globus pallidal GABA concentration measured by 1H-MRS.	—

Secondary

Measure	Time frame
Skill training information (music training history survey, the Goldsmiths Musical Sophistication Index score, the Barcelona Music Reward Questionnaire score), cognitive function (Japanese Adult Reading Test (JART), Letter Number Sequencing (LNS), Stroop Test, Trail Making Test (TMT)), and motor function (Simpson-Angus Scale, Barnes Akathisia Rating Scale, Abnormal Involuntary Movement Scale).	—

Countries

Japan

Contacts

Public ContactShinichiro Nakajima

Keio University School of Medicine

shinichiro.l.nakajima@gmail.com03-5363-3611

Outcome results