Balancing Rehabilitation Dose in Acute Stroke Decision-making and Global Evaluation

Balancing Rehabilitation Dose in Acute Stroke Decision-making and Global Evaluation - Balancing Rehabilitation Dose in Acute Stroke Decision-making and Global Evaluation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000057876

Enrollment

200

Registered

2026-06-01

Start date

2026-06-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Stroke patients (cerebral infarction or cerebral hemorrhage) expected to be hospitalized for 7 days or more 2. Age 18 years or more 3. Provision of informed consent 4. Initiation of rehabilitation by day 2 of admission

Exclusion criteria

Exclusion criteria: 1. Pre-hospitalization mRS 3 or more (unable to walk even with aids) 2. Terminal care patients or those with non-curative intent 3. Patients with anticipated prolonged immobility due to trauma (e.g., multiple unstable fractures, burns, amputations) 4. Inability to communicate in Japanese 5. Explicit refusal to allow use of clinical data for research

Design outcomes

Primary

Measure	Time frame
modified Rankin Scale (mRS) score at 90 days after stroke onset	—

Secondary

Measure	Time frame
The outcome measures of this study include the return-to-work rate, number of survival days, stroke recurrence rate, and Clinical Frailty Index (CFI) at 90 days after stroke onset. Additional outcomes include the length of hospital stay; handgrip strength and Barthel Index score at hospital discharge; in-hospital survival rate during admission; and neurological and functional assessments such as the National Institutes of Health Stroke Scale (NIHSS) score and Functional Ambulation Category (FAC). Rehabilitation-related variables assessed within the first week of admission include the intensity, frequency, and duration of rehabilitation, as well as the number of days to first mobilization. Furthermore, on day 7 after admission, the modified Rankin Scale (mRS) score, handgrip strength, and NIHSS score will be evaluated. Muscle status will be assessed using ultrasound to measure the cross-sectional area and thickness of the rectus femoris muscle. Additional physical assessments include calf circumference and nutritional status, evaluated using the Malnutrition Universal Screening Tool (MUST).	—

Measure

Time frame

The outcome measures of this study include the return-to-work rate, number of survival days, stroke recurrence rate, and Clinical Frailty Index (CFI) at 90 days after stroke onset. Additional outcomes include the length of hospital stay; handgrip strength and Barthel Index score at hospital discharge; in-hospital survival rate during admission; and neurological and functional assessments such as the National Institutes of Health Stroke Scale (NIHSS) score and Functional Ambulation Category (FAC). Rehabilitation-related variables assessed within the first week of admission include the intensity, frequency, and duration of rehabilitation, as well as the number of days to first mobilization. Furthermore, on day 7 after admission, the modified Rankin Scale (mRS) score, handgrip strength, and NIHSS score will be evaluated. Muscle status will be assessed using ultrasound to measure the cross-sectional area and thickness of the rectus femoris muscle. Additional physical assessments include calf circumference and nutritional status, evaluated using the Malnutrition Universal Screening Tool (MUST).

—

Countries

Japan

Contacts

Public ContactShinichi Watanabe

Gifu University of Health Science Department of Physical Therapy, Faculty of Rehabilitation

billabonghonor@yahoo.co.jp058-274-5001

Outcome results