Gastric cancer
Conditions
Interventions
None listed
Sponsors
International University of Health and Welfare Ichikawa Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. H. pylori-Negative Gastric Cancer Cases All patients diagnosed and treated for Helicobacter pylori (H. pylori)-negative gastric cancer during the study period will be included. The target population also includes gastric cancers located at the esophagogastric junction classified as Siewert type II or III, as well as gastric cancers occurring in patients with hereditary diffuse gastric cancer (HDGC), familial adenomatous polyposis (FAP), and other hereditary gastrointestinal cancer syndromes. H. pylori-negative status is defined as meeting all of the following criteria: i) At least one negative result in H. pylori diagnostic tests (e.g., serum anti-H. pylori IgG antibody, urea breath test, or direct microscopic examination of gastric mucosal biopsy specimens), ii) No endoscopic evidence of gastric mucosal atrophy, iii) No history of H. pylori eradication therapy. 2. H. pylori-Negative Non-Gastric Cancer Cases Patients confirmed to be H. pylori-negative and without evidence of gastric cancer on upper gastrointestinal endoscopy performed under the national health insurance system are eligible. To confirm H. pylori-negative status endoscopically, the following criteria are used: i) Presence of regular arrangement of collecting venules (RAC), ii) Presence of foveolar-hyperplastic red streaks (linear red streaks), hematin adherence, or fundic gland polyps, which are indicative of an uninfected gastric mucosa, iii) Absence of endoscopic atrophy, and iv) Absence of active H. pylori infection findings such as diffuse redness, increased mucus secretion, or thickened folds of the greater curvature of the gastric body. A comprehensive judgment is made based on these findings to confirm H. pylori-negative status.
Exclusion criteria
Exclusion criteria: Patients with an undetermined final pathological diagnosis will be excluded. In addition, H. pylori-negative gastric tumors classified as foveolar-type gastric adenomas -such as raspberry-type and flat-type lesions- will be excluded, as they are categorized as adenomas under the 5th edition of the WHO Classification of Tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy, precision, recall, AUC of the ROC curve, and RMSE of the constructed AI. | — |
Secondary
| Measure | Time frame |
|---|---|
| The background and lesion characteristics of H. pylori-naive gastric cancer cases and H. pylori-naive non-gastric cancer cases. | — |
Countries
Japan
Contacts
Public ContactFumiaki Ishibashi
International University of Health and Welfare Ichikawa Hospital Department of Gastroenterology
Outcome results
None listed