A Study on the Predictive Ability of Dynamic Arterial Elastance for Cardiac Output Increase Following Vasopressor Administration

A Study on the Predictive Ability of Dynamic Arterial Elastance for Cardiac Output Increase Following Vasopressor Administration - A Study on the Predictive Ability of Dynamic Arterial Elastance for Cardiac Output Increase Following Vasopressor Administration

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000057844

Enrollment

Registered

2025-05-13

Start date

2025-04-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients scheduled for surgery under general anesthesia with planned arterial catheter insertion

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing general anesthesia for surgery with planned arterial catheter insertion and intraoperative cardiac output monitoring

Exclusion criteria

Exclusion criteria: Patients with an ejection fraction <40% Patients with atrial fibrillation Patients with severe chronic obstructive pulmonary disease (COPD) Patients with right heart failure Patients with severe obesity (BMI>35) Patients with severe underweight or cachexia (BMI<15) Patients with preoperatively diagnosed hyperthyroidism

Design outcomes

Primary

Measure	Time frame
Change in stroke volume before and 10 minutes after initiation of continuous vasopressor infusion (norepinephrine at 0.05 mcg/kg/min, up to a maximum of 0.1 mcg/kg/min)	—

Secondary

Measure	Time frame
Change in cardiac output before and 10 minutes after initiation of continuous vasopressor infusion (norepinephrine at 0.05 mcg/kg/min assumed) Change in stroke volume and cardiac output before and 2 minutes after a single bolus of phenylephrine (0.1 mg); if multiple doses are administered, only the first dose is evaluated Assessment of the effectiveness of continuous vasopressor infusion: whether mean arterial pressure (MAP) reaches >65 mmHg, and/or whether MAP increases by >10%	—

Measure

Time frame

Change in cardiac output before and 10 minutes after initiation of continuous vasopressor infusion (norepinephrine at 0.05 mcg/kg/min assumed) Change in stroke volume and cardiac output before and 2 minutes after a single bolus of phenylephrine (0.1 mg); if multiple doses are administered, only the first dose is evaluated Assessment of the effectiveness of continuous vasopressor infusion: whether mean arterial pressure (MAP) reaches >65 mmHg, and/or whether MAP increases by >10%

—

Countries

Japan

Contacts

Public ContactYUSUKE IIZUKA

Jichi medical university, saitama medical center Department of anesthesiology and critical care medicine

zukarinn@gmail.com+81486472111

Outcome results