Healthy older adults
Conditions
Interventions
1) Subjects receive plant extract-containing supplements daily for 12 weeks. 2) Subjects receive a nutrition program four times during the intervention period.
1).Subjects receive of placebo for 12
Sponsors
Tokyo Metropolitan Institute for Geriatrics and Gerontology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Participants who have the capacity to provide informed consent, have received a thorough explanation of the purpose and details of the study, fully understand the information provided, and voluntarily agree in writing to participate in the study. 2) Participants who are men or women aged 65 years or older at the time of obtaining consent.
Exclusion criteria
Exclusion criteria: 1) Participants with a history of heart failure, myocardial infarction, or neurodegenerative diseases 2) Participants currently receiving treatment for atrial fibrillation, arrhythmia, liver dysfunction, renal dysfunction, cerebrovascular disease, rheumatoid arthritis, or diabetes 3) Participants diagnosed with dementia or those who scored 23 or lower on the Mini-Mental State Examination (MMSE) during a recent comprehensive health check-up 4) Participants with known or suspected allergies to broccoli, other foods, or medications 5) Participants who consume supplements, foods, quasi-drugs, or pharmaceuticals that may affect physical function or fatigue more than three times per week 6) Participants who consume broccoli sprouts or kale more than three times per week 7) Participants who consume supplements or green juice derived from broccoli, broccoli sprouts, kale, or wasabi more than three times per week 8) Participants who are currently enrolled in another clinical trial, have participated in another clinical trial within the past three months, or are expected to participate in another trial during the study period 9) Participants who are deemed unable to communicate effectively in Japanese 10) Participants who are deemed ineligible by the principal investigator or study physician due to illness or other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Between-group comparisons of changes from baseline to 12 weeks in the SF-36 Physical Component Summary, the 30-Second Chair Stand Test (30s-CST), and the 2-Minute Step-in-Place Test | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) SF36v2 2) Fatigue Visual Analog Scale 3) Muscle Strength 4) Usual Gait Speed 5) Skeletal Muscle Ultrasound Examination 6) Inflammatory Markers 7) Skeletal Muscle Atrophy Markers 8) Myofibrillar Protein Indicators 9) Oxidative Stress 10) Oxidative Stress Related Genes 11) Physical Activity | — |
Countries
Japan
Contacts
Public ContactTakashi Shida
Tokyo Metropolitan Institute for Geriatrics and Gerontology Research Team for Promoting Independence and Mental Health
Outcome results
None listed